LPHN1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA533903-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA533903 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
LPHN1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Adgrl1
Gene Alias
2900070I05Rik; ADGRL1; Adhesion G protein-coupled receptor L1; AI182398; calcium-independent alpha-latrotoxin receptor 1; Cirl; Cirl1; CIRL-1; CL1; CL1BA; CLIBA; KIAA0821; latrophilin 1; latrophilin-1; LEC2; Lectomedin-2; Lphh2; LPHN1; mKIAA0821
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
100359196, 100514215, 100760780, 22859, 330814, 65096, 788252
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry (Paraffin)
Concentration
0.74 mg/mL
Formulation
PBS with 0.1% sodium azide
Gene Accession No.
O88917, O94910, O97831, Q80TR1
Gene Symbols
Adgrl1
Immunogen
Synthetic 16 amino acid peptide from N-terminal extracellular domain of human LPHN1.
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Bovine, Hamster, Human, Mouse, Non-human Primate, Porcine, Rabbit, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Adgrl1 (Latrophilin-1) is a calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells
- Adgrl1 is a receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization, and may be implicated in the regulation of exocytosis
- The Adgrl1 gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR)
- Latrophilins may function in both cell adhesion and signal transduction
- In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane
- Adgrl1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane
- Alternative splicing results in multiple variants encoding distinct isoforms of Adgrl1
- Diseases associated with ADGRL1 include Dermatophytosis and Retinal Degeneration, Late-Onset, Autosomal Dominant.