200020229

PADI4 Monoclonal Antibody (C5), Invitrogen™

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

PADI4

Concentration

1 mg/mL

Classification

Monoclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4

Gene Alias

HL-60 PAD, PAD, PAD type IV, PAD4, Padi4, PADI5, PADI-H protein, PAD-R4, Pdi4, PDI5, peptidyl arginine deiminase 4, peptidyl arginine deiminase, type 4, peptidyl arginine deiminase, type IV, peptidyl arginine deiminase, type V, peptidylarginine deiminase IV, Peptidylarginine deiminase type alpha, protein-arginine deiminase type IV, Protein-arginine deiminase type-4

Gene Symbols

Padi4

Isotype

IgG2b κ

Purification Method

Protein A/G

Gene

Padi4

Clone

C5

Applications

Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Conjugate

Unconjugated

Host Species

Mouse

Target Species

Human

Gene Accession No.

Q9UM07

Gene ID (Entrez)

23569

Immunogen

Recombinant Human PADI4 protein, Met1-Pro300 (Accession #Q9UM07)

Primary or Secondary

Primary

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

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Description

  • Catalyzes the citrullination/deimination of arginine residues of proteins
  • Citrullinates histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription
  • Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.