KIR2DS4 Monoclonal Antibody (C15), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
KIR2DS4
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
CD158 antigen-like family member I, CD158I, killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4, killer cell immunoglobulin-like receptor 2DS4, killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 1, killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4, killer Ig receptor, killer inhibitory receptor 4-1-2, killer-cell immunoglobulin-like receptor, KIR antigen 2DS4, KIR1D, KIR2DS1, KIR2DS4, KIR-2DS4, KIR412, KKA3, MHC class I NK cell receptor, natural killer cell inhibitory receptor, natural killer cell receptor, natural killer-associated transcript 8, NKAT8, NKAT-8, p50 killer cell activating receptor KAR-K1d, P58 natural killer cell receptor clones CL-39/CL-17, p58 NK receptor CL-39/CL-17
Gene Symbols
KIR2DS4
Isotype
IgG2b κ
Purification Method
Protein A/G
Gene
KIR2DS4
Clone
C15
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human
Gene Accession No.
P43632
Gene ID (Entrez)
3809
Immunogen
Recombinant Human KIR2DS4 protein, Gln22-Ser302 (Accession #P43632)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
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Description
- Description Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells
- The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC)
- The gene content of the KIR gene cluster varies among haplotypes, although several "eframework"e genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2)
- The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain
- KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals
- The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.