SIGLEC7 Monoclonal Antibody (D5), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
SIGLEC7
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
Adhesion inhibitory receptor molecule 1, adhesion inhibitory receptor molecule 1, siglec-7, AIRM1, AIRM-1, CD328, CDw328, D-siglec, p75, p75/ AIRM-1, p75/AIRM1, QA79, QA79 membrane protein, sialic acid binding Ig like lectin 7, sialic acid binding Ig-like lectin 7, sialic acid binding immunoglobulin-like lectin 7, sialic acid-binding Ig-like lectin 7, Siglec, SIGLEC19P, SIGLEC7, SIGLEC-7, SIGLECP2
Gene Symbols
SIGLEC7
Isotype
IgG1 κ
Purification Method
Protein A/G
Gene
SIGLEC7
Clone
D5
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human, Rat
Gene Accession No.
Q9Y286
Gene ID (Entrez)
27036
Immunogen
Recombinant Human SIGLEC7 protein, Gln19-Ser336 (Accession #Q9Y286)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
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Description
- Putative adhesion molecule that mediates sialic-acid dependent binding to cells
- Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid
- Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide)
- The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface
- In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules
- Mediates inhibition of natural killer cells cytotoxicity
- May play a role in hemopoiesis
- Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).