BID Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Gorilla, Chimpanzee and Northern white-cheeked gibbon BID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2
• Bid is a member of the BCL-2 family of cell death regulators
• BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release
• BID is also a pro-apoptotic member of the Bcl 2 family
• BID usually exists in an inactive form in the cytosolic fraction of living cells and becomes cleaved and activated by caspase 8 in response to TNF alpha or Fas ligand
• Once BID is cleaved, the C-terminal 15 kDa fragment of BID (p15) translocates onto mitochondria and is sufficient to trigger cytochrome c release, resulting in cell apoptosis
• BID serves as a direct molecular link between caspase 8 activation and mitochondrial death machinery.