Phospho-SIRT2 (Ser331) Monoclonal Antibody (6B5), Active Motif™
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Phospho-SIRT2 (Ser331)
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias
5730427M03Rik; 5E5 antigen; mSIR2L2; NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2; Regulatory protein SIR2 homolog 2; silent information regulator 2; silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2; SIR2; SIR2L; SIR2L2; SIR2-like protein 2; sir2-related protein type 2; SIRT2; sirtuin 2; sirtuin type 2; sirtuin-2
Gene Symbols
SIRT2
Isotype
IgG2a
Purification Method
Protein G
Product Type
Antibody
Clone
6B5
Applications
Western Blot
Conjugate
Unconjugated
Host Species
Rat
Target Species
Human
Gene Accession No.
Q8IXJ6
Gene ID (Entrez)
22933
Immunogen
This antibody was raised against a synthetic peptide corresponding to human SIRT2 phosphorylated at Serine 331.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
SIRT2
Related Products
Description
- The SIRT2 protein (also known as Sirtuin for Silent Mating Type Information 2-Homolog) is a NAD-dependent deacytylase (NDAC) that has been shown to control gene silencing, cell cycle, and DNA damage repair
- It is believed that SIRT2 may act as a tumor suppressor in human gliomas and may also serve as a novel molecular marker for these cells
- SIRT2 has also been shown to act as a redox sensor to help regulate muscle gene expression in response to food intake and exercise
- SIRT2 acts in the phosphorylation cascade involving mitosis where SIRT2 is phosphorylated in late G2 phase, during M phase, and into cytokinesis.