MeCP2 Monoclonal Antibody (4H7), Active Motif™
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
MeCP2
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias
1500041B07Rik; AUTSX3; D630021H01Rik; DKFZp686A24160; Mbd5; MECP2; MeCp-2 protein; methyl CpG binding protein 2; methyl-CpG binding protein 2; Methyl-CpG-binding protein 2; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT; testis tissue sperm-binding protein Li 41a; WBP10
Gene Symbols
Mecp2
Isotype
IgG2a
Purification Method
Protein G
Product Type
Antibody
Clone
4H7
Applications
ChIP Assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Host Species
Rat
Target Species
Human, Mouse, Rat
Gene Accession No.
P51608, Q00566, Q9Z2D6
Gene ID (Entrez)
17257, 29386, 4204
Immunogen
This MeCP2 antibody was raised against a full-length protein corresponding to rat MeCP2.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
Mecp2
Related Products
Description
- MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3 and MBD4) that have a methyl-CpG binding domain
- MECP2 is capable of binding specifically to methylated DNA
- DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development
- MECP2 can also repress transcription from methylated gene promoters
- In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation
- MECP2 is dispensible in stem cells, but is essential for embryonic development
- MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.