7188579
5-Carboxylcytosine (5-caC) Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
5-Carboxylcytosine (5-caC)
Applications
Dot Blot
Conjugate
Unconjugated
Host Species
Rabbit
Formulation
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Isotype
IgG
Purification Method
Protein A
Product Type
Antibody
Concentration
1 mg/mL
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Immunogen
This 5-Carboxylcytosine antibody was raised against 5-carboxylcytidine conjugated to kLH and recognizes 5-carboxylcytosine.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Related Products
Description
- 5-carboxylcytosine is the final oxidized derivative of 5-methylcytosine, a type of DNA methylation
- 5-methylcytosine is oxidized to 5-hydroxymethylcytosine which is then oxidized to 5-formylcytosine and later to 5-carboxylcytosine
- These oxidations are catalyzed by the Ten-Eleven Translocation (TET) enzyme family
- 5-carboxylcytosine has been shown to cause reduced fidelity of RNA Polymerase II
- Decreased levels of 5-hydroxymethylcytosine has been found in some cancers.