7188576
3-Methylcytosine (3-mC) Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
3-Methylcytosine (3-mC)
Applications
Dot Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human, Mouse
Gene Alias
3mc; 3-mC; 3-meC; 3-Methyl-cytosine; C5H7NO3
Isotype
IgG
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Concentration
Conc. Not Determined
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
whole serum with 30% glycerol and 0.035% sodium azide; pH
Immunogen
This 3-methylcytosine antibody was raised against 3-methylcytidine conjugated to kLH and recognizes 3-methylcytosine .
Primary or Secondary
Primary
Product Type
Antibody
Related Products
Description
- 3-methylcytosine arises by erroneous methylation of DNA through spontaneous exposure to endogenous S-adenosyl methionine (SAM)
- Since the N3-position in cytosine is protected in double stranded DNA, this phenomenon mainly occurs in single stranded DNA
- The resulting 3-mC is toxic and mutagenic and increased levels of 3-mC seem to impair cell proliferation
- Therefore, it has to be repaired by the cell
- This is established by oxidative demethylation, which is catalyzed by the AlkB protein.