7188613
5-methylcytosine Recombinant Mouse Monoclonal Antibody, AbFlex™, Active Motif™
Mouse Recombinant Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
5-methylcytosine
Applications
Dot Blot
Conjugate
Unconjugated
Host Species
Mouse
Formulation
140mM HEPES, 35mM sodium acetate with 30% glycerol, 70mM NaCl and 0.035% sodium azide; pH 7.5
Immunogen
This antibody was raised against 5-methylcytosine conjugated to kLH.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Gene Alias
5mc; 5-mC; 5-meC; 5-Methyl-cytosine; C5H7NO3
Isotype
IgG2a
Purification Method
Protein A
Product Type
Antibody
Related Products
Description
- Methylation of DNA cytosine bases plays important roles in the regulation of gene transcription
- It has been estimated that 60 to 90% of the cytosines in CpG dinucleotides are methylated
- An increase in methyl-CpG correlates with transcriptional silencing for the whole chromosome especially in developmentally regulated genes
- Methylation is believed to lead to transcriptional silencing by multiple mechanisms including alteration of transcription factor binding to promoters and alteration in chromatin structure.