MilliporeSigma™ SMARCA3 (HLTF), Mouse, Unlabeled, Clone: 5-1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE1107MI-Each-of-1 | In Stock | ₹ 40,292.08 |
MABE1107MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
SMARCA3 (HLTF)
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q14527
Immunogen
GST-tagged recombinant human HLTF (SMARCA3) N-terminal fragment.
Quantity
100 μg
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_620636.1
Target Species
Human
Form
Purified
Applications
Immunohistochemistry (Paraffin)
Clone
5-1
Conjugate
Unconjugated
Gene
HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 5-1 detected predominantly nuclear HLTF (SMARCA3) immunoreactivity by immunohistochemistry staining. Clone 5-1 epitope lies within an N-terminal region present in both spliced isoforms of human HLTF reported by UniProt (Q14527).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Helicase-like transcription factor (UniProt Q14527; also known as DNA-binding protein/plasminogen activator inhibitor 1 regulator, HIP116, RING finger protein 80, Sucrose non-fermenting protein 2-like 3, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) is encoded by the HLTF (also known as HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1) gene (Gene ID 6596) in human
- Helicase-like transcription factor (115kDa)is a SWI/SNF (mating-type switching/sucrose non-fermenting) protein that uses ATP hydrolysis to remodel chromatin in multiple cellular processes
- It is shown to regulate transcription by binding to the SV40 enhancer and the promoters Serpin E1 and HIV-1
- It is well expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle
- It was initially characterized for its DNA binding and transcriptional activity, however, later was shown to act as an E3 ubiquitin ligase and was implicated in post-replication DNA repair by polyubiquitination of proliferating cell nuclear antigen (PCNA)
- The inactivation of HIP116 is shown to induce an elevated level of chromosome breaks and fusions in mouse embryonic fibroblasts after treatment with alkylating agents
- HIP116 inactivation in transgenic mice is reported to disrupt cell cycle at the G2/M phase.