MilliporeSigma™ PASD1, Mouse, Unlabeled, Clone: 2ALCC136,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE1110-Each-of-1 | In Stock | ₹ 40,292.08 |
MABE1110 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
PASD1
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG2a in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q8IV76
Immunogen
GST-tagged recombinant human PASD1 fragment corresponding to the region between the PAS domain and the second coiled coil region.
Quantity
100 μg
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_775764
Target Species
Human
Form
Purified
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
2ALCC136
Conjugate
Unconjugated
Gene
PASD1
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 2ALCC136 (a.k.a. PASD1-1) recognizes both human PASD1 spliced isoforms reported by UniProt (Q8IV76), as well as a novel ∽40 kDa isoform (Cooper, C.D., et al. (2006). Leukemia. 20(12):2172-2174).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2a κ
Related Products
Description
- Circadian clock protein PASD1 (UniProt Q8IV76; also known as Cancer/testis antigen 63, CT63, OX-TES-1, PAS domain-containing protein 1) is encoded by the PASD1 gene (Gene ID 139135) in human
- Originally characterized as a lymphoma-associated antigen and a candidate cancer/testis antigen (CTA), PASD1 is evolutionarily related to CLOCK and interacts with the bHLH-PAS transcription complex CLOCK-BMAL1 to repress transcriptional activation
- PASD1 expression is normally limited to immunologically restricted germline tissues that do not express class I MHC molecules, such as testis and placenta, allowing tissue-specific circadian rhythms suppression
- PASD1 can be induced in cells of somatic origin upon oncogenic transformation and PASD1 is among the most frequently expressed acute myeloid leukemia (AML) tumour antigens
- Reducing PASD1 in human cancer cells significantly increases the amplitude of transcriptional oscillations to generate more robust circadian rhythms
- Human PASD1 gene is located on Xq28, and mutations in the q28 region have been linked with increased risk of lymphoma and leukemia, Human PASD1 contains an N-terminal PAS domain (a.a
- 30-102), a central region (a.a
- 365-412) essential for its transcriptional repression activity, and two coiled coil domains (CC1/a.a
- 365-412 and CC2/a.a
- 475-553), where CC1 exhibits significant homology with CLOCK exon 19-coded sequence.