MABN1529MI
MilliporeSigma™ PRICKLE2, Mouse, Unlabeled, Clone: 3B4.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN1529MI-Each-of-1 | In Stock | ₹ 38,958.86 |
MABN1529MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,958.86
GST (18%): ₹ 7,012.595
Total Price: ₹ 45,971.455
Antigen
PRICKLE2
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q7Z3G6
Immunogen
GST-tagged recombinant human PRICKLE2 internal fragment.
Quantity
100 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_942559
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
3B4.1
Conjugate
Unconjugated
Gene
PRICKLE2, EPM5
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 3B4.1 targets an internal PRICKLE2 epitope conserved between human and murine species.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2a κ
Related Products
Description
- Prickle-like protein 2 (UniProt Q7Z3G6) is encoded by the PRICKLE2 (also known as EPM5) gene (Gene ID 166336) in human
- Prickle2 is a nuclear membrane associated protein that belongs to a highly conserved Prickle, Espinas, Testin (PET) and Linl-1, Isl-1, and Mec-3 (LIM) domain-containing protein family
- Prickle is part of the non-canonical Wnt signaling pathway that establishes planar cell polarity
- It plays a critical role in neuron architecture and function
- In mice it is shown to be highly expressed in the hippocampus region where it localizes to the post-synaptic density (PSD)
- It interacts the PSD-95 and NMDA receptor, the two proteins implicated in Autism spectrum disorders
- Loss of Prickle2 is known to reduce number and size of miniature synaptic currents, indicating deficits in basal synaptic transmission
- Mice deficient in Prickle2 exhibit lower seizure threshold and PRICKLE2 mutations in humans are associated with progressive myoclonic epilepsy type 5
- Ref.: Sowers, LP., et al.
- (2013), Mol
- Psychiatry
- 18, 1077-1089.