MABS1131MI
MilliporeSigma™ SFRP3, Mouse, Unlabeled, Clone: 14G11.2,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1131MI-Each-of-1 | In Stock | ₹ 40,292.08 |
MABS1131MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
SFRP3
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q92765
Immunogen
GST-tagged recombinant human SFRP3 Netrin (NTR) domain fragment.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_001454
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
14G11.2
Conjugate
Unconjugated
Gene
FRZB, FIZ, FRE, FRP, FRZB1, SFRP3
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 14G11.2 recognizes an epitope within the netrin (NTR) domain of human secreted frizzled-related protein 3 (sFRP-3).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2b κ
Related Products
Description
- Secreted frizzled-related protein 3 (UniProt Q92765; also known as Frezzled, Fritz, FrzB-1, Frizzled-related protein 1, sFRP-3) is encoded by the FRZB (also known as FIZ, FRE, FRP, FRZB1, SFRP3) gene (Gene ID 2487) in human
- Canonical Wnt signaling is constitutively suppressed in the absence of Wnt, and its activation in the presence of Wnt can be blocked by secreted inhibitors, including the dickkopf-related proteins (DKK) and the secreted frizzled-related proteins (sFRP1-5)
- sFRPs share homology with the FZD receptor and compete againt FZD for Wnt binding in the extracellular space, sFRPs may also exert their effects by interacting with each other and FZD receptors
- sFRP-3 plays a role in regulating cell growth and differentiation in specific cell types, such as adult hippocampal neural stem cell activation and chondrocyte maturation
- sFRP-3 is produced with a signal peptide sequence (a.a
- 1-32), the removal of which yields the mature protein with an N-terminal FZ (a.a
- 33-150) domain, followed by a netrin (NTR) domain (a.a
- 178-298) and a C-terminal Ser-rich region.