MABS1228MI
MilliporeSigma™ ANKRD1/CARP, Mouse, Unlabeled, Clone: 12G8.2,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1228MI-Each-of-1 | In Stock | ₹ 40,633.84 |
MABS1228MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,633.84
GST (18%): ₹ 7,314.091
Total Price: ₹ 47,947.931
Antigen
ANKRD1/CARP
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q15327
Immunogen
GST-tagged recombinant human ANKRD1/CARP fragment corresponding ankyrin repeats 4&5.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_055206
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Applications
Western Blot
Clone
12G8.2
Conjugate
Unconjugated
Gene
ANKRD1, C193, CARP, HA1A2
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Related Products
Description
- Ankyrin repeat domain-containing protein 1 (UniProt Q15327; also known as Cardiac ankyrin repeat protein, Cytokine-inducible gene C-193 protein, Cytokine-inducible nuclear protein) is encoded by the ANKRD1 (also known as C193, CARP, HA1A2) gene (Gene ID 27063) in human
- ANKRD1/CARP belongs to a family of conserved muscle ankyrin repeat proteins (MARPs), members of which also include ANKRD2 and diabetes ankyrin repeat protein (DARP, ANKRD23)
- ANKRD1 is highly expressed in cardiomyocytes and known to interact with myopalladin and titin, implicating its roles in myopalladin complex-dependent sarcomere integrity maintenance and stress-induced gene regulations medidated by the titin complex
- ANKRD1 is up-regulated in patients with dilated cardiomyopathy and in animal models of cardiac hypertrophy induced by pressure overload and adrenergic stimulation
- ANKRD1 is shown to regulate the hypertrophic agonist phenylephrine-/PE-induced α-adrenergic signaling pathway in neonatal rat ventricular myocytes, where it recruits and localizes ERK1/2 and GATA4 in a sarcomeric complex, resulting in enhanced GATA4 phosphorylation and subsequent ANKRD1 complex nuclear translocation and gene activation.