MABS1198MI
MilliporeSigma™ SPINK1, Mouse, Unlabeled, Clone: 4D11.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1198MI-Each-of-1 | In Stock | ₹ 42,968.31 |
MABS1198MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,968.31
GST (18%): ₹ 7,734.296
Total Price: ₹ 50,702.606
Antigen
SPINK1
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P00995
Immunogen
GST-tagged recombinant human SPINK1.
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_003113
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
4D11.1
Conjugate
Unconjugated
Gene
SPINK1, PCTT, PSTI, TCP
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Expected to react with both pro- and mature human SPINK1.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Serine protease inhibitor Kazal-type 1 (UniProt P00995; also known as Pancreatic secretory trypsin inhibitor, TATI, Tumor-associated trypsin inhibitor) is encoded by the SPINK1 (also known as PCTT, PSTI, TCP) gene (Gene ID 6690) in human
- Serine protease inhibitor Kazal-type 1 encoded by the human SPINK1 gene functions as an acute-phase protein (APP) in the pancreas
- Produced initially in a 79-a.a
- proform, the signal peptide (a.a
- 1-23) is removed posttranslationally to yield the 56-a.a
- (a.a
- 24-79) mature protein
- SPINK1 protein blocks premature activation of trypsinogen (inactive form of trypsin), thereby ensuring the integrity of acinar cells to prevent auto-digestion of the pancreas
- SPINK1 is also reported to play a role in tissue repair, apoptosis, reproduction, and behave as a growth factor in other human organs
- In addition, SPINK1 protein is known as tumor-associated trypsin inhibitor or TATI and current research activities are focused on the association of various cancers to deregulated SPINK1 activity.