RARA Monoclonal Antibody (763), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA14668-Each-of-1 | In Stock | ₹ 47,481.50 |
MA14668 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
RARA
Classification
Monoclonal
Conjugate
Unconjugated
Gene
RARA
Gene Alias
Nr1b1; nuclear receptor subfamily 1 group B member 1; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; RAR; RAR Alpha; RAR alpha 1; RARA; RAR-alpha; RARalpha1; retinoic acid; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear receptor alpha variant 2; retinoic acid receptor; retinoic acid receptor alpha; retinoic acid receptor, alpha; retinoic acid receptor, alpha polypeptide; RRA
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
19401, 24705, 5914
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Clone
763
Formulation
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.
P10276, P11416
Gene Symbols
RARA
Immunogen
Synthetic peptide corresponding to the N-terminal region of human RARA conjugated to KLH
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- This antibody is predicted to react with bovine, canine, guinea pig and mouse based on 100% sequence homology
- This antibody is specific for the ∽48 kDa RXR-1 protein
- RARA is a receptor for retinoic acid
- Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes
- The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5
- In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression
- On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation
- RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis
- Has a role in the survival of early spermatocytes at the beginning prophase of meiosis
- In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes
- In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function
- Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5
- Mediates retinoic acid-induced granulopoiesis.