CaMKII alpha Recombinant Rabbit Monoclonal Antibody (JM11-07), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532610-Each-of-1 | In Stock | ₹ 53,088.50 |
PIMA532610 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,088.50
GST (18%): ₹ 9,555.93
Total Price: ₹ 62,644.43
Antigen
CaMKII alpha
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P11275, P11798, Q9UQM7
Gene Symbols
CAMK2A
Immunogen
Synthetic peptide within Human CaMKII alpha aa 37-71
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunoprecipitation, Western Blot
Clone
JM11-07
Conjugate
Unconjugated
Gene
CAMK2A
Gene Alias
alpha CaM kinase II, alpha-CaMKII, Ca2+/calmodulin-dependent protein kinase II, Ca2+/calmodulin-dependent protein kinase II alpha, Calci, calcium/calmodulin dependent protein kinase II alpha, calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha, calcium/calmodulin-dependent protein kinase II alpha, calcium/calmodulin-dependent protein kinase II alpha subunit, calcium/calmodulin-dependent protein kinase II alpha-B subunit, calcium/calmodulin-dependent protein kinase type II alpha chain, calcium/calmodulin-dependent protein kinase type II subunit alpha, CaM kinase II alpha subunit, caM kinase II subunit alpha, CaMK II, CAMK2, Camk2a, CAMKA, CaMKII, CaMK-II alpha subunit, caMK-II subunit alpha, CaMKIINalpha, CaM-kinase II alpha chain, EC 2.7.11.17, KIAA0968, mKIAA0968, OTTHUMP00000165787, OTTHUMP00000165788, Phospho-CaMKI, PK2CDD, PKCCD, R74975
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
12322, 25400, 815
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- CAMK2A (CaMKII alpha) is a serine/threonine kinase that regulates a number of cellular functions including neuronal processes, gene expression, carbohydrate metabolism, cytoskeletal function, and calcium homeostatsis
- Autophosphorylation of threonine 286 in the presence of Ca2+ and calmodulin activates CAMK2A with the ability to switch from calmodulin-dependent to a calmodulin independent activity
- CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+/calmodulin (CaM) binding and autophosphorylation and has been implicated in regulation of the cell cycle and transcription
- It is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle
- In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner.