Complement C4 Recombinant Rabbit Monoclonal Antibody (JM88-13), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532856-Each-of-1 | In Stock | ₹ 46,947.50 |
PIMA532856 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,947.50
GST (18%): ₹ 8,450.55
Total Price: ₹ 55,398.05
Antigen
Complement C4
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P0C0L4, P0C0L5
Gene Symbols
C4A, C4B
Immunogen
Synthetic peptide within Human C4 aa 1231-1280
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
JM88-13
Conjugate
Unconjugated
Gene
C4A
Gene Alias
acidic C4, acidic complement C4, Basic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3, C4, c4 complement, C4-1, C4a, C4a anaphylatoxin, C4A2, C4A3, C4A4, C4A6, C4AD, C4B, C4B_2, C4B1, C4B12, C4B2, C4B3, C4B5, C4b-A, C4b-B, C4BD, C4d-A, C4d-B, C4F, C4S, CH, Chido form of C4, CO4, Complement C4, Complement C4 alpha chain, Complement C4 beta chain, Complement C4 gamma chain, Complement C4-A, Complement C4-A alpha chain, Complement C4-B, Complement C4-B alpha chain, complement C4B1a, complement component 4 (within H-2S), complement component 4, gene 1, complement component 4A (Rodgers blood group), complement component 4B (Chido blood group), complement component 4B (Childo blood group), CPAMD2, CPAMD3, DADB-112B14.11, DAMC-258G8.6, FLJ60561, MGC164979, MHC class III region complement, RG, Rodgers form of C4, sex-limited protein, Slp, Ss
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
100293534, 720, 721
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- This gene encodes the acidic form of complement factor 4, part of the classical activation pathway
- The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion
- The trimer provides a surface for interaction between the antigen-antibody complex and other complement components
- The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation
- Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus
- This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6
- Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.