CD61 (Integrin beta 3) Recombinant Rabbit Monoclonal Antibody (RM382), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA533041-Each-of-1 | In Stock | ₹ 47,837.50 |
PIMA533041 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,837.50
GST (18%): ₹ 8,610.75
Total Price: ₹ 56,448.25
Antigen
CD61 (Integrin beta 3)
Classification
Recombinant Monoclonal
Concentration
0.1 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.
P05106
Gene Symbols
ITGB3
Immunogen
A peptide corresponding to the internal region of human Integrin beta3.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
RM382
Conjugate
Unconjugated
Gene
ITGB3
Gene Alias
antigen CD61, BDPLT16, BDPLT2, beta3 integrin, CD61, EGK_08849, glycoprotein GPIIIa, glycoprotein IIIa, GP3A, GPIIIa, GT, INGRB3, integrin beta 3, integrin beta 3 (Cd61), integrin beta-3, integrin beta-3 subunit, integrin subunit beta 3, integrin, beta 3, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61), ITGB3, platelet glycoprotein IIIa, platelet glycoprotein IIIa integrin subunit beta 3, platelet gpIIIa, platelet membrane glycoprotein IIIa
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
3690
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- Specificity: reacts to Human Integrin beta3A/CD61
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets and their precursors
- CD61 antigen plays a role in platelet aggregation and also as a receptor for fibrinogen, fibronectin, von Willebrand factor and vitronectrin
- CD61 is a 105 kDa glycoprotein that associates with either the alpha 11b integrin (CD41) or the alpha V integrin (CD51) at the cell surface
- CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51
- CD61 is a receptor for fibrinogen, fibronectin, Von Willebrand Factor, vitronectin and thrombospondin
- The CD61 protein product is composed of an alpha chain and a beta chain
- A given chain may combine with multiple partners resulting in different integrins
- CD61 is found along with the alpha IIb chain in platelets
- Like other integrins, CD61 is known to participate in cell adhesion as well as cell-surface mediated signaling
- Diseases associated with CD61 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.