CD49b (Integrin alpha 2) Recombinant Rabbit Monoclonal Antibody (SN0752), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532306-Each-of-1 | In Stock | ₹ 46,413.50 |
PIMA532306 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,413.50
GST (18%): ₹ 8,354.43
Total Price: ₹ 54,767.93
Antigen
CD49b (Integrin alpha 2)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P17301, Q62469
Gene Symbols
Itga2
Immunogen
Synthetic peptide within Human Integrin alpha 2 aa 1,132-1,181
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SN0752
Conjugate
Unconjugated
Gene
Itga2
Gene Alias
alpha 2 subunit of VLA-2 receptor, BDPLT9, BR, CD49 antigen-like family member B, CD49B, Collagen receptor, DX5, GPIa, HPA-5, human platelet alloantigen system 5, integrin alpha 2, integrin alpha-2, integrin subunit alpha 2, integrin, alpha 2, integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), Itga2, platelet antigen Br, platelet glycoprotein GPIa, platelet membrane glycoprotein Ia, very late activation protein 2 receptor, alpha-2 subunit, VLA-2, VLA2 receptor, VLA-2 receptor, alpha 2 subunit, VLA-2 subunit alpha, VLAA2
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
16398, 170921, 3673
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family
- It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex
- VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways
- It has reported roles in VEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation
- CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells
- It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.