CD41 Recombinant Rabbit Monoclonal Antibody (JM11-19), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532596-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532596 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
CD41
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P08514
Gene Symbols
Itga2b
Immunogen
Synthetic peptide within Human CD41 aa 41-74
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry, Western Blot
Clone
JM11-19
Conjugate
Unconjugated
Gene
Itga2b
Gene Alias
AI172977, alpha IIb, alphaIIb, alphaIIb protein, BDPLT16, BDPLT2, CD41, CD41B, form 1, form 2, GP IIb, GP2B, GPalpha IIb, GPIIb, GT, GTA, HPA3, integrin alpha 2b, integrin alpha 2b (Cd41b), integrin alpha-IIb, Integrin alpha-IIb heavy chain, Integrin alpha-IIb light chain, Integrin alpha-IIb light chain, form 1, Integrin alpha-IIb light chain, form 2, integrin subunit alpha 2b, integrin subunit alpha IIb, integrin, alpha 2B, integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), ITGA2B, ITGAB, platelet fibrinogen receptor, alpha subunit, platelet glycoprotein IIb, platelet glycoprotein IIb of IIb/II Ia complex, platelet glycoprotein IIb of IIb/IIIa complex, platelet membrane glycoprotein IIb, platelet-specific antigen BAK, PPP1R93, protein phosphatase 1, regulatory subunit 93
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
3674
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- CD41 (platelet glycoprotein IIb, ITGA2B) is composed of two subunits -120 kDa a, alpha and 23 kDa b, beta- that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor
- CD41 is also involved in blood coagulation by mediating platelet aggregation
- Upon blood vessel damage, CD41 binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin
- CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during the early stages of hematopoietic differentiation
- Diseases associated with CD41 dysfunction include Glansmann Thrombasthenia, and Platelet type-16 bleeding disorder.