CD61 (Integrin beta 3) Recombinant Rabbit Monoclonal Antibody (SJ19-09), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532077-Each-of-1 | In Stock | ₹ 46,413.50 |
PIMA532077 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,413.50
GST (18%): ₹ 8,354.43
Total Price: ₹ 54,767.93
Antigen
CD61 (Integrin beta 3)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
O54890, P05106
Gene Symbols
ITGB3
Immunogen
Synthetic peptide within Human Integrin beta 3 aa 729-788
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SJ19-09
Conjugate
Unconjugated
Gene
ITGB3
Gene Alias
antigen CD61, BDPLT16, BDPLT2, beta3 integrin, CD61, EGK_08849, glycoprotein GPIIIa, glycoprotein IIIa, GP3A, GPIIIa, GT, INGRB3, integrin beta 3, integrin beta 3 (Cd61), integrin beta-3, integrin beta-3 subunit, integrin subunit beta 3, integrin, beta 3, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61), ITGB3, platelet glycoprotein IIIa, platelet glycoprotein IIIa integrin subunit beta 3, platelet gpIIIa, platelet membrane glycoprotein IIIa
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
16416, 29302, 3690
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets and their precursors
- CD61 antigen plays a role in platelet aggregation and also as a receptor for fibrinogen, fibronectin, von Willebrand factor and vitronectrin
- CD61 is a 105 kDa glycoprotein that associates with either the alpha 11b integrin (CD41) or the alpha V integrin (CD51) at the cell surface
- CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51
- CD61 is a receptor for fibrinogen, fibronectin, Von Willebrand Factor, vitronectin and thrombospondin
- The CD61 protein product is composed of an alpha chain and a beta chain
- A given chain may combine with multiple partners resulting in different integrins
- CD61 is found along with the alpha IIb chain in platelets
- Like other integrins, CD61 is known to participate in cell adhesion as well as cell-surface mediated signaling
- Diseases associated with CD61 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.