PIPA5105243
Phospho-RPH3A (Ser424) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5105243-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5105243 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Phospho-RPH3A (Ser424)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
RPH3A
Gene Alias
2900002P20Rik; AU022689; AW108370; Exophilin 1; Exophilin1; Exophilin-1; KIAA0985; rabphilin 3A; rabphilin 3A homolog; rabphilin-3A; RPH3A
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
171039, 19894, 22895
Content And Storage
-20°C
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P47708, P47709, Q9Y2J0
Gene Symbols
RPH3A
Immunogen
A synthesized peptide derived from human RPH3A(Accession Q9Y2J0), corresponding to amino acid residues around phosphorylated Ser424.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of Rabphilin 3A only when phosphorylated at Ser424
- The carboxy-terminal of rabphilin-3A consists of two C2 domains, A and B, and the amino-terminal (residues 45-170) contains a cysteine-rich rich region with two zinc finger motifs
- Rabphilin-3A belongs to a family of other carboxyterminal type (C-type) tandem C2 proteins, which includes synaptotagmins and Doc2
- Rabphilin is expressed in neuroendocrine cells and co-localizes with Rab3A on synaptic vesicles and chromaffin granules
- Rabphilin-3A binds Rab3a/GTP/Mg+ within amino-terminal residues 45 and 170
- Rabphilin-3A binds calcium ions and phosphatidylinositol 4,5-bisphophate containing lipid vesicles within its C2 domains
- Rabphilin-3A is a positive regulator of calcium dependent exocytosis, while Rab3a is a negative regulator of exocytosis
- Although rabphilin-3A associates with Rab3a, they seem to influence exocytosis independently of each other
- Rabphilin-3A effects are likely mediated through interactions with an unknown factor that recognizes the Rab3 binding domain.