Phospho-Dynamin 1 (Ser774) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5104963-Each-of-1 | In Stock | ₹ 45,345.50 |
PIPA5104963 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,345.50
GST (18%): ₹ 8,162.19
Total Price: ₹ 53,507.69
Antigen
Phospho-Dynamin 1 (Ser774)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DNM1
Gene Alias
AI838169; B-dynamin; D100; Dnm; Dnm1; Dyn1; dynamin 1; Dynamin BREDNM19; dynamin i; dynamin, brain; Dynamin1; Dynamin-1; EC 3.6.5.5; EIEE31; Ftfl; Kiaa4093; mKIAA4093; Neuronal dynamin; OTTHUMP00000215500
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
13429, 140694, 1759
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P21575, P39053, Q05193
Gene Symbols
DNM1
Immunogen
A synthesized peptide derived from human DNM1(Accession Q05193), corresponding to amino acid residues around phosphorylated Ser774.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of Dynamin 1 only when phosphorylated at Serine 774
- Dynamin is a GTPase required for endocytosis of clathrin coated vesicles from the membrane
- Dynamin's involvement in endocytosis was first discovered during the characterization of the temperature sensitive parylytic shibire mutation from Drosophila melanogaster
- Three closely related isoforms have been identified in mammals
- Dynamin1 is expressed exclusively in neurons, dynamin2 is ubiquitously expressed and dynamin3 is expressed primarily in the testes
- Each of these isoforms of dynamin also has several splice variants
- This suggests that each isoform/splice variant may have separate intracellular targets or function in the budding of distinct vesicle types
- Common domain features of the dynamin proteins include an amino acid terminal GTPase domain, a central pleckstrin homology domain and a highly basic proline rich carboxyl terminus with several Src homology 3 (SH3) domains
- These SH3 domains target the dynamin to the clathrin coated pit
- Dynamin is known to interact with at least two proteins, AP2 adaptor protein complex and amphiphysin.