CD319 (CRACC) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA595799-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA595799 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
CD319 (CRACC)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SLAMF7
Gene Alias
19A, 19A24, 19A24 protein, 4930560D03Rik, CD2 subset 1, CD2-like receptor activating cytotoxic cells, CD2-like receptor-activating cytotoxic cells, CD319, CRACC, CS1, Leukocyte cell-surface antigen, membrane protein FOAP-12, Novel Ly9, novel LY9 (lymphocyte antigen 9) like protein, protein 19A, RGD1560190, SLAM family member 7, SLAMF7, UNQ576/PRO1138
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
364049, 57823, 75345
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
0.76 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.
Q8BHK6, Q9NQ25
Gene Symbols
SLAMF7
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 23-226 of human SLAMF7 (NP_0670043)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: SGPVKELVGS VGGAVTFPLK SKVKQVDSIV WTFNTTPLVT IQPEGGTIIV TQNRNRERVD FPDGGYSLKL SKLKKNDSGI YYVGIYSSSL QQPSTQEYVL HVYEHLSKPK VTMGLQSNKN GTCVTNLTCC MEHGEEDVIY TWKALGQAAN ESHNGSILPI SWRWGESDMT FICVARNPVS RNFSSPILAR KLCEGAADDP DSSM; Positive Samples: A-549, THP-1, Jurkat, 22Rv1; Cellular Location: Membrane, Single-pass type I membrane protein SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain
- Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway
- It may play a role in lymphocyte adhesion
- Isoform 3 does not mediate any activation
- SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro)
- SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea
- Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines
- The isoform 3 is expressed at much lower level than isoform 1
- There are three named isoforms.