Synaptotagmin 1 Monoclonal Antibody (ASV30), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA125568-Each-of-1 | In Stock | ₹ 53,400.00 |
MA125568 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,400.00
GST (18%): ₹ 9,612.00
Total Price: ₹ 63,012.00
Antigen
Synaptotagmin 1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.1mM PMSF, 50% glycerol and no preservative; pH 7.2
Gene Accession No.
P21707, P46096, P48018
Gene Symbols
Syt1, syt1.L
Immunogen
Rat brain synaptic junctional protein complexes.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Bovine, Mouse, Rabbit, Rat, Shark, X. laevis
Product Type
Antibody
Isotype
IgG2a
Applications
Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Clone
ASV30
Conjugate
Unconjugated
Gene
Syt1
Gene Alias
AW124717; DKFZp781D2042; FLJ42519; G630098F17Rik; P65; SV DKFZp781D2042; SV SYT; svp65; Syb1; synaptotagmin 1; synaptotagmin 1 L homeolog; synaptotagmin 2; synaptotagmin I; synaptotagmin I protein; synaptotagmin I variant b; Synaptotagmin II; Synaptotagmin XI; synaptotagmin-1; Synaptotagmin-2; SYT; Syt1; syt1.L; SYT2; SytI; SytII; XELAEV_18022019mg
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
100350072, 20979, 25716, 281511, 447431
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recommended positive controls: Mouse or Rat brain tissue extract.
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS and is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release
- Studies indicate that synaptotagmin’s Ca2+ mediated binding of SNAP25 is essential for the Ca2+ dependent triggering of membrane
- It has been demonstrated that discrete residues within the c(2)b binding domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size
- Synaptotagmin 1 may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse
- Further, Synaptotagmin 1 binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone
- A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has been reported
- Synaptotagmin 1 can also bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2
- Diseases associated with the dysfunction of Synaptotagmin 1 include food-borne botulism and infant botulism.