CD103 (Integrin alpha E) Recombinant Rabbit Monoclonal Antibody (SN62-06), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532278-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532278 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
CD103 (Integrin alpha E)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P38570
Gene Symbols
Itgae
Immunogen
Synthetic peptide within Human Integrin alpha E aa 1-50
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry
Clone
SN62-06
Conjugate
Unconjugated
Gene
Itgae
Gene Alias
A530055J10, alpha-E1, alpha-M290, aM290, antigen CD103, antigen CD103, human mucosal lymphocyte antigen 1, alpha polypeptide, CD103, DC, DCs, HML-1 antigen, human mucosal lymphocyte antigen 1, alpha polypeptide, HUMINAE, integrin alpha E, integrin alpha E, epithelial-associated, integrin alpha E1, epithelial-associated, integrin alpha M290, Integrin alpha-E, Integrin alpha-E heavy chain, Integrin alpha-E light chain, Integrin alpha-IEL, integrin subunit alpha E, integrin, alpha E, integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1, alpha polypeptide), integrin, alpha E, epithelial-associated, Intregrin alpha E2, Itgae, MGC141996, Mucosal lymphocyte 1 antigen
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
3682
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- CD103 (ITGAE, Integrin alpha E) is molecule that is expressed on mucosa-associated T lymphocytes and activated cells and on subet of TGF beta -1 cells
- In particular, CD103 includes a 150kDa alpha chain and a 120kDa beta chain
- CD103 is expressed by 0.5 to 2% of resting lymphocytes in peripheral blood and lymphoid organs
- CD103 antibody stains a few bone marrow cells and, rarely, peripheral blood lymphocytes
- CD103 is part of the integrin family which are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain
- ITGAE encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains
- In combination with the beta 7 integrin, CD103 protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen
- CD103 is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation
- Diseases associated with CD103 dysfunction include hairy cell leukemia and splenic marginal zone lymphoma.