ITGA4 Recombinant Rabbit Monoclonal Antibody (JA09-36), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532677-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532677 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
ITGA4
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P13612, Q00651
Gene Symbols
ITGA4
Immunogen
Synthetic peptide within Human Integrin alpha 4 aa 983-1032
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunohistochemistry, Western Blot
Clone
JA09-36
Conjugate
Unconjugated
Gene
ITGA4
Gene Alias
269C wild type, alpha 4 subunit of VLA-4 receptor, antigen CD49D, alpha-4 subunit of VLA-4 receptor, CD49 antigen-like family member D, CD49d, IA4, integrin alpha 4, integrin alpha-4, integrin alpha4B, Integrin alpha-IV, integrin subunit alpha 4, integrin, alpha 4, integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor), Itga4, Itga4B, ITGA-IV, LPAM subunit alpha, lymphocyte Peyer patch adhesion molecules subunit alpha, very late activation protein 4 receptor, alpha 4 subunit, VLA-4 receptor, alpha 4 subunit, VLA-4 subunit alpha
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
16401, 311144, 3676
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins
- Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains
- Alpha4 chain associates with either beta1 or beta7 chain
- It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain
- These ligands included Madcam, VCAM, and fibronectin
- Madcam is known as the principal ligand for integrin alpha4beta7
- Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.