Caspase 14 Recombinant Rabbit Monoclonal Antibody (JJ089-01), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532458-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532458 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
Caspase 14
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
O89094, P31944
Gene Symbols
Casp14
Immunogen
Recombinant protein within Human Caspase-14 aa 80-220
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
JJ089-01
Conjugate
Unconjugated
Gene
Casp14
Gene Alias
apoptosis-related cysteine protease, CASP14, CASP-14, caspase 14, caspase 14, apoptosis-related cysteine peptidase, caspase 14, apoptosis-related cysteine protease, Caspase14, caspase-14, Caspase-14 subunit p10, mature form, Caspase-14 subunit p17, mature form, Caspase-14 subunit p20, intermediate form, Caspase-14 subunit p8, intermediate form, caspase-14, LOW QUALITY PROTEIN: caspase-14, MICE, Mini-ICE
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
12365, 23581, 299587
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Caspase 14 encodes a member of the cysteine-aspartic acid protease (caspase) family, which plays a central role in the execution-phase of cell apoptosis
- Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme
- This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo
- The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier
- Diseases associated with CASP14 include Ichthyosis, Congenital, Autosomal Recessive 12 and Autosomal Recessive Congenital Ichthyosis.