Caspase 9 Recombinant Rabbit Monoclonal Antibody (2D5), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA533121-Each-of-1 | In Stock | ₹ 50,596.50 |
PIMA533121 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,596.50
GST (18%): ₹ 9,107.37
Total Price: ₹ 59,703.87
Antigen
Caspase 9
Classification
Recombinant Monoclonal
Concentration
1.75 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.
P55211
Gene Symbols
CASP9
Immunogen
A synthesized peptide derived from human CASP9
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
ELISA, Flow Cytometry, Immunocytochemistry, Western Blot
Clone
2D5
Conjugate
Unconjugated
Gene
CASP9
Gene Alias
25 kDa caspase-9 dominant negative protein, AI115399, APAF3, APAF-3, apoptotic protease activating factor 3, apoptotic protease MCH-6, Apoptotic protease-activating factor 3, AW493809, cas9, CASP 9, CASP9, CASP-9, Casp9_v1, Casp-9-CTD, caspase 9, caspase 9, apoptosis-related cysteine peptidase, caspase 9, apoptosis-related cysteine protease, Caspase9, caspase-9, caspase-9 dominant negative form, Caspase-9 precursor, Caspase-9 subunit p10, Caspase-9 subunit p35, CASPASE-9c, caspase-9-carboxyl-terminal divergent, CTD, Ice-Lap6, ICE-like apoptotic protease 6, Mch6, OTTHUMP00000002324, PPP1R56, protein phosphatase 1, regulatory subunit 56, RNCASP9, RP11-265F14.3
Host Species
Rabbit
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
842
Content And Storage
-20°C or -80°C if preferred
Form
Liquid
Related Products
Description
- Caspase 9 (ICE-like apoptotic protease 6, ICE LAP6, apoptotic protease Mch6, apoptotic protease activating factor 3, Apaf3) is a member of the peptidase family C14 that contains a CARD domain
- Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates
- Caspase 9 is active as a heterotetramer, is present in the cytosol and, upon activation, translocates to the mitochondria
- Caspase 9 is involved in the caspase activation cascade responsible for apoptosis execution and cleaves/activates Caspase 3 and Caspase 6
- Further, Caspase 9 is involved in the activation cascade of caspases responsible for apoptosis execution
- Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3
- Caspase 9 promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner, and proteolytically cleaves poly(ADP- ribose) polymerase (PARP)
- Caspase 9 is expressed in variety of human tissues
- An isoform of rat Caspase-9 has been identified in which the C terminus of full-length Caspase-9 is replaced with an alternative peptide sequence
- Mutations in Caspase 9 affect brain development
- In mice, insufficient Caspase 9 have resulted in abnormal cerebrum development and neuron development
- In humans, dysfunctional Caspase 9 expression vary from tissue to tissue
- Low levels of Caspase 9 may play a role in cancer development and neurodegenerative diseases such as Alzheimer’s Disease (AD).