MABS1697MI
MilliporeSigma™ WISP-3, Mouse, Unlabeled, Clone: 13C4.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1697MI-Each-of-1 | In Stock | ₹ 42,968.31 |
MABS1697MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,968.31
GST (18%): ₹ 7,734.296
Total Price: ₹ 50,702.606
Antigen
WISP-3
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
O95389
Immunogen
GST-tagged recombinant human WISP-3 IGFBP domain fragment.
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_003871
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
13C4.1
Conjugate
Unconjugated
Gene
WISP3, CCN6, LIBC, PPAC, PPRD, UNQ462/PRO790/PRO956
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 13C4.1 targets an epitope within the WISP-3 IGFBP domain.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
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Description
- Lymphocyte cytosolic protein 2 (UniProt: Q13094; also known as Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP-76 tyrosine phosphoprotein, SLP76) is encoded by the gene LCP2 (Gene ID 3937) in human
- SLP-76 is a cytoplasmic adaptor phosphoprotein that contains both SH2 and SAM domains and is involved in B and T cell receptor signaling
- Its amino terminus contains an acidic region that includes a PEST domain and several tyrosine residues that are phosphorylated following TCR ligation
- SLP-76 also contains a central proline-rich domain and a SH2 domain at its carboxy terminal
- SLP-76 can be phosphorylated on multiple tyrosine residues by the upstream kinases ZAP-70 and Lck
- SLP-76 phosphorylation plays an important role in T cell-mediated IL-2 production by allowing phosphorylated Vav to bind and this complex stimulates NFAT and IL-2 gene activation after TCR engagement
- SLP-76 is highly expressed in spleen, thymus, and peripheral blood leukocytes and T cells
- It is expressed in B cell lines at lower levels and is not detected in fibroblast and neuroblastoma cell lines
- SLP-76 is reported to play a positive role in promoting T cell development and activation as well as mast cell and platelet function
- Overexpression of SLP-76 is shown to enhance IL-2 transcription after TCR signaling.